Conserving ovarian tissue in treatment of ovarian neoplasms.

The serial indirect M.B.C. readings of each individual after the three test inhalants have been scrutinized. After the inhalation of deptropine citrate alone, the highest reading of 14 of the 20 patients occurred between 150 and 210 minutes ; the highest reading of the remaining patients occurred at 90 minutes (two patients), at 120 minutes (two patients), and at 60 minutes in one patient. The trial had to be discontinued after 15 minutes in one patient owing to severe asthma. Four individuals were substantially worse 15 minutes after the inhalation of deptropine citrate-that is, all these patients showed a drop in their indirect M.B.C. of 25% or more. None of these four patients, who showed this marked deterioration after the inhalation of deptropine citrate, showed a similar deterioration after the inhalation of the inert propellant. After the inhalation of deptropine citrate and isoprenaline, the highest reading was observed at 15 minutes (six patients), at 30 minutes (two patients), at 60 minutes (three patients), at 90 minutes (one patient), at 120 minutes (three patients), at 180 minutes (two patients), and at 210 minutes (three patients). Roughly half the patients showed a sustained effect after reaching their peak indirect M.B.C. over the 210-minutes period of observation. Fifteen minutes after the inhalation of the inert propellant there was only one patient who showed an improvement of 10% or more in the indirect M.B.C., most patients showed a slight drop. Peak readings of individuals after the inhalation was uniformly scattered throughout the 210 minutes of observation, but, as the group results showed, there was a general tendency for values to increase by 3 to 4% throughout the morning.